Complicated orolingual angioedema after recombinant tissue plasminogen activator treatment in stroke patients under angiotensin converting enzyme inhibitor: Report of two cases
نویسندگان
چکیده
1 Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran 2 Care Sciences, and Society (NVS), Karolinska Institute AND Department of Neurobiology, Stockholm, Sweden AND Firoozgar Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences; Tehran, Iran 3 Firoozgar Clinical Research Development Center AND Department of Neurology, School of Medicine, Firoozgar Hospital, Iran University of Medical Sciences; Tehran, Iran
منابع مشابه
Orolingual and abdominal angioedema post thrombolysis and thrombectomy.
A 53-year-old man treated with an angiotensin-converting enzyme (ACE) inhibitor presented with left hemiplegia (NIH Stroke Scale 23). Magnetic resonance angiography revealed a right proximal middle cerebral artery occlusion (figure 1). Thirty minutes after thrombolysis, orolingual swelling was observed. Two hours later, just after mechanical thrombectomy was completed, he developed painful abdo...
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Systemic thrombolysis with the recombinant tissue plasminogen activator (rtPA) is an effective therapy option in the treatment of acute ischaemic stroke [1]. A rare but potentially fatal side effect is the development of an orolingual angioedema [2]. Because of improvements in acute stroke therapy and an aging population the incidence of recurrent strokes is increasing and results in more patie...
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Objective: Currently, treating ischemic stroke by intravenous thrombolytic therapy has acceptable results in patients with stroke. This study aimed to evaluate the three months prognosis of patients treated with recombinant tissue plasminogen activator (rt-PA).Methods: This cross-sectional prospective study was conducted on 30 patients with cerebral ischemic stroke with the National Insti...
متن کاملBiochemical basis of angioedema associated with recombinant tissue plasminogen activator treatment: an in vitro experimental approach.
BACKGROUND Angioedema has been reported during recombinant tissue plasminogen activator (rtPA) treatment of acute ischemic stroke, often with concomitant use of angiotensin I-converting enzyme inhibitor treatment. Angioedema has been partly attributed to the nonapeptide bradykinin (BK), although its precise role has been poorly documented until now. The purposes of this report are 2-fold. First...
متن کاملLingual angioedema with macroglossia during the treatment of acute ischemic stroke with alteplase
Alteplase (recombinant tissue plasminogen activator) has been used in the treatment of acute ischemic stroke for 10 years. The application of this drug is considered safe and effective. However, alteplase is also associated with side effects. The author is reporting on an unusual side effect of angioedema that is triggered by alteplase. Angioedema occurs through alteplase according to this stud...
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